Rathan Mouli made his acting debut in Unnaiyae Kadhalipaen (2010), before going on to work in Parameshwar's Karumpuli (2013) and Anand's unreleased Theal. While his first film went largely unnoticed, Karumpuli (2013) gained attention prior to release after the Censor Board had recommended several changes owing to its story on terrorism. Rathan Mouli then collaborated with director Pughazhmani on back-to-back horror films, 13 am Pakkam Parkka (2015) opposite Sri Priyanka and Vellikizhamai 13 am Thethi (2016) opposite Suza Kumar. His first release in 2017 was the rural action film Arasakulam, while his upcoming films include Malli and Sei (a) Sethumadi.