Karine Isambert was born in France and grew up in Paris. At the age of 12, she was discovered by a radio director and she worked as a radio show host every Saturday evening. Later, studying in the University, she started working part-time as a model and moved to NYC. After that, she did roles in short movies. She played majors roles in many plays including Dona Ana in Don Juan (2010) and Katia in Le Carton, Oscar in Love (2015). In 2012, she founded her production company Revenescences. In 2015, she made a short film Victory about Paris attacks.