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The Mind Explorers: a psychedelic weekend follows ordinary people on an extraordinary trip. The documentary centres around a 4-day psychedelic retreat in the Netherlands, where psilocybin-containing 'magic truffles' are legal. With new research suggesting that psychedelics can treat depression effectively, accessible retreats abroad are appealing to a new wave of curious 'psychonauts'. Following participants before, during and after the experience, the film explores the potential of psychedelics to transform people's lives in the long term when taken in a therapeutic setting.