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In a future where the world is grossly over populated, the UN has issued a 'decree of departure', selecting 50 people per state at random every day from the 'Life Lottery' to be expired by one of the nation's Bio Restraint Officers, known on the streets as Grippers. They use a specialized glove, designed to expire their clients painlessly and efficiently, whilst simultaneously taking a sample of their blood to put toward research for modern medicine. Numbers Up follows the journey of one of these Grippers, Dean Marching, and his battle with fate, duty and the value of human life.