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Like many scientists, Nathan Dale dreams of a breakthrough in one of the world's most complex illnesses-drug addiction. When an old colleague summons him to study the Iboga root, he seizes the opportunity and embarks on a research trip to Mouila, Gabon. Along with his best students-Matt, Emily, Megan and Andy-he hopes to finally make a difference in the war against drug addiction. At first everything seems to go as planned. But as their research brings them deeper into places even the Gabonese villagers themselves fear to disturb, they learn that Iboga is not just a candidate for drug addiction treatment; for the natives, it is a gateway to the spirits' world. When hallucinations start to devour the scientists' reality, they lose their ability to distinguish the world in which they exist. Soon the line between the spirits' world and reality becomes blurry. Will they find the way out? Only the Spirit of The Ngounie River knows if they are worthy enough to survive.
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