This film contains even more drug use than the first film. Extreme use of multiple drugs and alcohols.
As a result of the Na'vi learning humans ways, many of the Na'vi use drugs and alcohol, and many are addicted.
The Na'vi mostly use drugs during sex.
Muklup and Le'toh snort heroin out of a woman's butt crack. They then turn the woman around and pour crushed Xanax pills, cocaine and weed in between her breasts. They then snort the drugs off her breasts. The brothers then have sex with the woman.
Neytiri's mother Mo'at smokes weed frequently, and uses drugs during sex.
During a Na'vi party, over 20 people are seen having rough unprotected sex. Most of them consume drugs and alcohol while doing so.
Mo'at has sex with 4 humans. After the men ejaculate on her boobs, Mo'at lines cocaine onto each man's penis and snorts it off.
Throughout the film, Jake Sully gets increasingly addicted to cocaine. At the end of the film, Jake has sex with Rachel and snorts cocaine off her breasts, stomach and back. He also snorts heroin out of her butt crack.