A character who is a recovering heroin addict is seen relapsing, getting out their heroin 'kit' (with spoon, rubber tubing, needle, etc). We see that character prepare to shoot heroin into their arm, then cut to a scene later where the character is obviously strung out and high. We see the kit more than once, and in one scene we do see the whole process of tying off the arm and actually injecting the heroin, the character moans and slumps back in their chair, nodding out with tubing loosened slightly and the needle still in the person's arm.
A character smokes a joint at a party and shares one hit with another character.
Heavy cigarette smoking by at least one major character throughout the second half of the movie.
A woman takes RX sleeping medication (that a doctor legally prescribed, due to her insomnia) in one instance.