A pretty hefty amount of sexual references. Any possible nudity, however, is completely void of detail, simply featuring (at the most) bare, smooth skin.

One episode has a man, well... sticking his penis inside of a bullet wound; obviously not seen onscreen.

Frequent talk about increasing the length of one man's penis is discussed in one episode.

It is implied Victor's wife, Elizabeth, is having an affair.

Victor Frankenstein is said to be a masochist, whom frequently shoots himself below the torso in order to achieve sexual satisfaction.

Some. The animation style doesn't allow for anything particularly graphic.

People are attacked by werewolves, shot, etc., but most of these acts of violence never have consequences due to many characters' immortality.

Infrequent use of mild swear words including Hell, Damn and Ass.

Characters are sometimes shown drinking at a bar.

Many jokes can (and probably will) offend, including gags about Hitler, race and the stereotypes that come with, et cetera.

Some episodes do feature adult themes, although when compared to the creator's other animated series, Moral Orel, it is far less serious in this regard.