Bare breasts are briefly shown.

A couple perform an anal sex on the couch. A man penetrates and thrusts vigorously. A part of a girl's bare breast is visible. However no sensitive areas are shown in this scene.

One make out scene between Laura and George; fully clothed. Meanwhile George exposes Laura's bare belly. Afterwards they are laying on the bed under the quilts. sex is implied. No nudity is shown.

A couple have sex on a bed. Woman is on top thrusting. Her fully exposed breasts are hanging down.

Some sexual references and jokes.

Some of the jokes in the stand-up scenes include sexual references.

There is a brief although comic fight scene in which a character is seen with a bloody face.

164 uses of "fuck", 70 uses of "shit", 35 uses of the crass word "cock", about 50 uses of "damn" and "hell". Sexual language is quite strong in the standup scenes.

Characters drink quite a bit, but not really to excess, although it seems to amplify bad behavior among the characters.

There is references to tobacco.

Mark briefly smokes pot from a bowl pipe.

There is some emotional moments that have to do with the cancer that George has.

This is not your average Judd Apatow movie (i.e. Superbad, The 40 Year Old Virgin). This is a serious movie that has a comedian cracking very funny jokes every once in a while. One minute you're watching a hardcore drama, the next you're laughing hysterically.