James Franco's character discusses a fight with his girlfriend and shouts things

A room in a night club, where there's multiple women dressed like prostitutes, around a man, in the middle of them. Implying that he's having sex with one or more of them.

At the very end, two characters are shown rolling in the grass making out

a few mild references to menstruation

At least 6 uses of the word "vagina", all of which are in the end credit bloopers

Sexual references.

Several motions of main characters "penis" in movie.

The wife is wearing a very low-cut dress that shows lots of cleavage.

Fairly restrained by most comedies by comparison

Blackmail-type photos of a man with women kissing are shown briefly.

Tina Fey's character is briefly seen stuffing her bra.

Steve Carell's character and Tina Fey's character have a discussion about "fooling around" in bed

One muscle man (Mark Wahlberg) is shirtless in a couple of scenes.

James Franco asks Steve Carell's character to "zip his mouth". "Zip your mouth" comes up several times.

A character mentions having sex twice a week.

Steve Carell's character makes a remark about his wife's breasts.

Two characters are held at gunpoint

Some shooting at, but with no blood and no deaths.

One comical car chase scene.

Lots of crude swearing and sexual references including fuck, goddamn, damn, shit, bitch, Jesus, Jesus Christ, ass, hell, vagina, penis, sex, anal sex, whacking off, lap dance, strip clubs, backdoor, fooling around, quickie, crap and more

One use of the F-word, one use of "goddamn," four uses of "shit," six uses of "bitch," and multiple mild religious exclamations.

In the DVD/Blu-ray's gag reel there are two additional uses of the F-word.

People drink beer in a strip club

A girl's name is Whip-It. One woman assumes it to be named after the dog Whippet but Whip-It graphically explains what a Whip-It is ( "Like when you violently inhale and squirt nitrous out of a whipped cream can, getting you high'').

Some drinking of wine. Main characters appear to be mildly intoxicated at one point.

One character appears to be high. He is seen biting his nails and playing with his hair in a hyperactive manner, implying use of cocaine.

Some chase scenes, one car chase scene, and some gun use. People are threatened that they will be shot but it is done in a comical manner. There is also shootings, mostly from the bad guys in the movie