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It is 1916. The doctor of botany Lily Houghton embarks on a dangerous mission to change the world. Along with her brother, McGregor, Dr Houghton enlists the help of the arrogant scoundrel riverboat skipper, Captain Frank Wolff, to guide them through the Amazon River. As the trio wanders further and further into the gigantic, imposing forest in the search for something that cannot be found, they will encounter many wild and unimaginable challenges which will put in risk such a courageous endeavor.