Quite a few of the adult characters smoke during the movie. The major female character is seen taking some sort of drug in a pill form, probably the Aponeuron that she purchases later (a medication that the body converts to amphetamine). It is not clear whether it is really illegal or not - the context is that the state would prohibit her from taking this particular drug but not necessarily because it is immoral.
The protagonist and another character are sharing a drink from a bottle. The gentleman has several other bottles there as well. The protagonist lights up a cigarette at this time also.
There are several scenes where characters drink cocktails. In one scene two of the major characters are in a quiet bar, and the male drinks two shots of vodka while the female drinks a shot of cognac. There is no scene in the movie where anyone is shown to be intoxicated.