Lots of slapstick. Brain often bops Pinky on the head for doing and saying idiotic things. However, Pinky often laughs after he's hit. In some episodes, weapons like guns can be seen, but no blood or deaths are ever shown.

"Ass" is used multiple times in the segment "A Little Off The Top" featured in Episode 20.

In one episode, Brain is addicted to cigarettes. This episode often demonstrates how smoking is bad for your body, showing people coughing violently, having bad teeth, looking older than they really are, etc. At the end, Brain states that he is trying to quit, asking Pinky for a nicotine patch. This episode won an award for its anti smoking message.

Some young children may be frightened by the fact that The Brain's main goal is to take over the world. However, he always fails in the end and this is a very light- hearted and comedic show.