Two women are briefly seen kissing in a bathroom stall.

A little sexual discussion.

Michael J Fox make a slightly drunken pass at a co-worker but she gently rebuffs him.

Ironically, this very serious film's one scene of violence is played primarily as comic relief.

There is some profanity in the film, mild and strong.

17 uses of fuck, and many uses of shit, ass, damn, and goddamn.

Jamie is heavily addicted to cocaine and alcohol in the movie.

The film's primary theme is addiction. So, we see cocaine being snorted several times throughout the film including a scene where Michael J Fox does lines on a coffee table and another where he gets a nosebleed from his cocaine abuse.

Alcohol is regularly consumed in clubs, parties, and other social venues. Jason Robards' character is in a state of severe inebriation every moment he is on screen even to the point where he seems to be hallucinating at times and babbles incoherently and talks with slurred speech. Fox's character has a drunken moment or two.

Cigarettes are smoked in some scenes.

Fox has a dream where he talks to bizarre looking baby that could creep out some people(the scene is brief).

Flashbacks to Fox's mother who is dying of cancer and his depression over her death is one of the reasons that he drinks and does drugs.