Not really any except for a couple of crude jokes.
Violence & Gore
Mild
Lots of shooting. An explosion. Some fist fights (including pushing/punching etc) however there is no blood at all
There is no blood as the violence is merely done for adventure as well as comedy. Cop shoot outs and the like. Overall, very mild.
Profanity
Severe
Many abuses of "Christ" and "Jesus."
119 uses of 'fuck,' and a few uses of "shit" and "son of a bitch." Some is done for comedy; some is present in the scenes with the Mafia.
Alcohol, Drugs & Smoking
Moderate
Smoking in almost every scene
Jack (De Niro) smokes throughout the movie, and there's also a scene where a man is sitting in a bar and drinking.
Frightening & Intense Scenes
Mild
A mobster threatens a man sitting in the back of his limo, and tells him that he is going to kill him and his wife. He then slaps the man in the face. This is probably the most menacing scene of the movie.
Rated R: For Pervasive Strong Language Throughout, and for Some Violence.