Flatbed Annie & Sweetiepie: Lady Truckers (1979)

After Sweetiepie's husband, who is a trucker, got wounded in a shootout, she has to think up some way to pay the rates for the superliner. Together with a remote friend of her husband, Flatbed Annie (a trucker without a truck), she takes up trucking. What they all didn't know: there is cocaine hidden in the truck somewhere. And not only the bad guys are after it.