We see a boy pick up a needle. It's strongly implied that his mother is a drug addict.
We hear about a girl who used to use different prescription pills before throwing them out.
We see bottles of beer; drinking is mentioned in conversation.
We see a woman getting stopped at a Land Port of Entry and the security guard asks her for her purse, where he pills out a white paper bag - supposedly filled with narcotics.
We see characters drinking backstage.
We see a boy walk in on his mother with bottles of pills and needles lying on the bed and a woman, with face sores, unconscious. It's heavily implied that she died of an overdose.
We see a woman with facial sores from repeated substance abuse.