The story revolves around drug dealers in a small Appalachian town. A character deals opioid painkillers that he gets from elderly folks in the town. References are made to cooking drugs (presumably crack and meth) and heroin dealing.
A character smokes a joint and offers it to another character.
Several characters snort cocaine in different scenes.
A character suffering from addiction is seen at several points soliciting dealers to get high. We see a character give her a small stash of pills.