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Kicking the Hornet's Nest is a startling investigative look at a popular gynecologic device used to perform hysterectomies that has been inadvertently spreading cancer in patients for decades. Weaving together first-person testimonies and archival footage, the film follows two married Harvard-affiliated whistle-blowers, personally impacted by the procedure, as they mount a harrowing campaign against the medical establishment to expose the controversial practice and prevent future needless deaths.