There is a character who can transform into a refrigerator and freeze people to death. This is why another character puts an electric plug into his butt, thinking it would charge him.

A character is told to "eat himself" while his 50 pizzas are being prepared.

A quote in a Marvel Studios-style studio logo reads "Let's enter the asshole! Challenge accepted!"

An event where a character "entered the asshole in the ground" is recounted several times.

Characters put a cable with plugs on both ends into their butts to transfer the ability to fly from one person to the other, and a second time to transfer it back. This is accompanied by several sexual jokes.

Due to the new animation style, the violence is significantly more graphic and realistic than in the previous installment.

A character recounts how he literally exploded.

A half human-half cat species is created to kill birds more effectively. All the humans and cats explode during the experiment.

A fire causes an explosion of a huge building. This is not shown, but mentioned.

Global warming wipes out an entire planet. This is only shown from space.

A character laughs at the fact that one billion humans died in a natural disaster.

A flashback shows characters fighting by shooting lasers at each other.

A character recounts killing three of his friends, and how much he enjoyed it. Two of these murders are accompanied by flashbacks. He recounts this again later.

A character says he wants to cut off a bird character's wings to fly away from where he is.

A character's hand gets cut off, and he emits an extremely painful scream. A cat then walks up to the hand, and starts eating it. It is later mentioned (not shown) that the cat "ate some of it, and threw the rest into the swimming pool". This is especially disturbing because it's played for laughs. This is the most violent scene in the film.

A character gets shot at with a stun gun, and loses consciousness.

A character graphically vows to kill a certain other character, but never does.

In the scene following a character's hand getting cut off, a sea of blood coming from where the hand used to be is building up on the floor. The character repeatedly asks for a doctor during the scene, and gets told to be patient. He drops dead at the end of the scene. This is especially disturbing because it's played for laughs.

When a characters asks what they should do with a (human) corpse, the answer is "get it to the kitchen". This is never brought up again or explained.

When a character points out that he lost his hand, he gets scolded for not applying bandage to his own wound, and gets told that he will have to clean up the sea of blood himself.

A character is sad at the fact that the people he left behind on a planet didn't die, and that he can't see their corpses now.

A character says he once blew up a planet.

Most viewers won't notice this before it's pointed out to them, but in a scene that takes places backstage behind a live TV studio, the audience can be heard repeatedly chanting "Kill him".

During a surgery scene, blood is coming out of a cut in the patient's body.

A surgeon confuses the stomach tube with his phone, and it rings inside the stomach. This is played for laughs.

Violence is repeatedly played for laughs.

A surgeon cuts a stomach with scissors.

A character repeatedly shoots at another character with a laser gun.

Characters say they knew that another character just let an entire planet die, and they are fine with it.

A character recounts cleaning up blood all around a village.

When laying out a risky plan, a character says that a lot of people might die, but that he doesn't care.

Characters trick another group of characters into filling up their oceans with liquid carbon dioxide, which they think is water, and they look forward to it with joy.

A character wishes "long, painful deaths that rip their bodies apart, down to the last cell, and every single atom they are made up of" on other characters, and adds that they deserve it.

A character repeatedly implies that he's going to kill a certain other character if he questions his authority.

14,000,605 spaceships destroy 14,000,605 other spaceships by flying into them kamikaze-style. It is implied that everyone on board dies.

A character destroys 49 spaceships, and presumably, everyone on board, with her heat vision.

A surgeon asks another character for his kitchen knife because it would be useful during surgery.

A character tries to rip out his own tongue, but bites his hand in the process, screams in pain, and blood is sprayed out of the wound, onto the walls.

A character rips out another character's tongue, and huge amounts of blood are flying onto the wall. Two characters then ask him for more blood, so they can use it as wall paint. The tongue is then plugged back in.

A surgeon gets a call saying that he forgot scissors inside a patient.

A running gag that is played for laughs is that a surgeon character repeatedly forgets things inside his patients.

An appropriate rating would be: Rated R for strong language throughout, some bloody violence, and some sexual humor.

This is one of the most profanity-heavy films that have ever been made in English. 385 uses of "fuck", 103 uses of "ass"/"asshole", 26 uses of "shit", 16 uses of "damn", and 11 uses of "shut up"/"shut the fuck up".

A character says "What a fucking asshole" out of nowhere, for no apparent reason. This is his only line in the film.

A character tells another character not to say the word "fuck", while saying "fuck" in the sentence himself.

Characters are very rude to each other, even when they're not using profanity.

During a phone conversation, characters briefly talk about someone else's mild alcohol consumption.

Characters drink vodka together in a scene.

A character says that he likes being drunk, but that he hates the taste of vodka.

A surgeon asks if he can take a bottle of vodka home to use it as painkiller for his patients, so they come back because of the effects of alcohol, pay more money to the hospital, and ultimately, to him.

Characters recount how their planet dried out.

Birds can talk like humans in the universe of the film. Some characters, both human and bird, are bigoted against the other group.

A character is sucked into a portal, and emits a scream, but not a very painful one.

A character screams in pain after falling out of a portal in the sky.