Two characters attempt to have sex as well as continuously dialogue about having sex in the Season 2 episode "Zoey's Extraordinary Distraction."

Religious expressions like Jesus and my God.

The first segment of every episode closes with a character (usually Zoey) trying to utter a profanity, at which point the speaker's mouth is covered up by graphics revealing the show's title. It is this running gag that is the basis for the show's TV-14-L rating in the US.

Casual drinking by adults. References to weed.

Zoey's father is slowly dying from disease. The family struggles to deal with it.