In one of the last episodes, they are looking at a camp list and it says to pack 'Ladies Items'. The further going on to mention pads and tampons
In the wedding episode, one of the girls gets her period, then further being told how to put on a pad
Some kissings (mostly between adults) and a brief kiss scene between two middle-schoolers
In episode 1, a character mentions that she has a college level art class and she would be drawing people nude. She also says "I'm not nude, they're nude" (she is a 12 year old)
Two quick kisses. between some teens
Season 2 is more open about the topics like having baby's and "doing it with the right man" but it's all in a brief description that'll go over kids heads but parents might get it
Mentions New friend's dad is gay and reason for divorce