Characters are shown drinking, smoking cigarettes and doing drugs. There is marijuana use and some cocaine and heroin use.
Throughout the entire 6 seasons there is drinking smoking and drug use
Frequent paraphernalia and references
In a party scene there they take a drug gush and get high and in another party people are seen drinking smoking joints and snorting cocaine (brief).
BoJack's an alcoholic
A young Bojack is forced to smoke an entire pack of cigarettes as punishment for stealing one from his mother.
A young Beatrice is forced to take "pretty pills" for weight loss.
We see bags of heroin with a characature of Bojack on them.
There are implications regarding drug use in almost every episode, where characters will passingly remark on situations/incidents or other characters in conjunction with drug use, and some episodes feature actual drug use being depicted by various characters in the series. Pills and other forms of drug paraphernalia can be seen in the background occasionally in almost every episode as well.
One of BoJack's former co-stars is (implied)severely addicted to drugs throughout the series whenever she is present.
BoJack is a welcomer to alcoholism and drinks different forms of alcohol (e.g. bourbon, whiskey, tequila, etc.) in almost every episode. He drinks from a flask frequently, at one point is shown drinking a few consecutively in a flashback. (In the series opening title, BoJack is depicted getting drunk at a party, at one point holding a glass of alcohol, then stumbling over the edge of his penthouse into his pool.)
BoJack is also a frequent cigarette smoker and is shown passively smoking a cigarette in some episodes, obviously under a nicotine addiction.
Various characters, other than BoJack, are also seen drinking alcohol and getting adversely drunk in some episodes.
[Season 1]
There are different depictions of drug use in this season, including one long, somewhat excessive portrayal of drug use and the effects of drug use covering an entire episode.
When BoJack meets his former co-star in 'Episode 3', she is implied to be under the effects of drugs constantly, and at one point, does handful of pills. BoJack then questions her whether that is the appropriate way to consume prescription drugs.
BoJack is severely intoxicated off-screen in 'Episode 6', so much that he steals the 'D' work from the 'Hollywood' sign. Only the aftermath is show, and his intoxication is only discussed.
BoJack is shown very intoxicated in a couple of episodes, with many beer cans surrounding him.
A race figure that BoJack looked up to during his childhood years is implied to have taken steroids and testosterone-enhancing drugs after he is revealed to have cheated on the racetrack.
A young boy asks BoJack's agent, disguised as a man in a trench-coat, 'Would you like a alcohol?'
[Season 2]
One of BoJack's friends, at one point, gives up on her life temporarily and sleeps at his house, to which she becomes increasingly lazy and frequently consumes beer. She eventually brings him into her psyche, and they drink a horrendous amount of beer, at one point organizing the empty beer cans into various monuments offscreen.
At one point in the same episode, while BoJack passively talks to his annoyed girlfriend, he and his friend smoke from a bong somewhat offscreen. One closeup shows his friend lighting the bong and smoking with bubbles heard.
In one episode, a disturbing flashback shows BoJack, as a kid, sneaking a cigarette packet from his mother's purse and taking one out and smoking it, to his discomfort, before his mother comes in and marks her indifference to his actions, instead showing her disappointment in his existence, and forces him to finish the cigarette. This scene is sad, disturbing and very distressing.
One of the episodes features BoJack smoking a joint in a close-up very briefly.
BoJack's golden retriever friend is shown wearing a dog cone in 'Episode 1', after he could not stop biting his stitches due to him punching a mirror in a drunken stupor. This is only discussed.