Several moments of offscreen nudity. Nothing is ever shown, just implied.
Often, there are dirty references with Marco's parents.
Some characters are shown in loincloths, notably Star's dad. It becomes more common toward the middle of the series. Played for laughs.
Characters are called "hot" kind of frequently.
Violence & Gore
Mild
Some mild gore and/or slight injury detail. No blood is ever shown, except when an 8-bit videogame character is decapitated and some red pixels appear to float onscreen.
Comical mild fantasy violence on a regular basis. Sometimes it gets more serious though.
Profanity
Mild
Very mild language ("heck", "jerk", "butt"...). A character is always called "Earth-turd" by another character.
Marco says what the hell in one episode
Alcohol, Drugs & Smoking
None
One of Star's Spells can cause a victim to hallucinate.
Star and her friends experiences a "trip" after eating "Goblin Dogs" which look like regular hot dogs. But afterwards they are not damaged by the effects only feeling amazed by the taste.
Frightening & Intense Scenes
Mild
Similar to "Invader Zim" the show could sometimes come to a comical way of some of the more frightening moments.
There are emotional moments.
"The Battle for Mewni" Movie has some of the most intense moments in the show. Particularly Toffee's parts at the beginning and at the end.