Alien drugs are used frequently. However, Rick snorts a pink alien drug and there are also scenes of aliens smoking hookahs or getting high. Rick also smokes out of a pipe or bong, and Summer and Morty get high off a spaceship's break fluid. They are shown smoking it multiple times.
A party boat has graphic drug use. Adults drink in the background, cigarette butts on the ground and plates of edibles, a woman is shown smoking a joint, cutting up and snorting cocaine, and a couple roll up joints and smoke them, as well as bong smoking graphically. Also, other people snort cocaine.
Cocaine is used a couple of times throughout the series. For example, in a dream sequence, a large pile of cocaine is snorted by two characters.
A drug lord is shown with paraphernalia all around him like pills and rolls paper with powder in it.
An alien smokes a hookah and Morty accidentally inhales it. Also, in season 2, aliens smoke hookahs.
A couple of times, cigarettes are smoked but they are usually pretty brief. However, there is one scene depicting gambling and cigar smoking.
A party in the second season is shown with tons of drinking, and a bong is shown in multiple scenes, but they smoke it offscreen.
There is a party in the first season with underage drinking.
One episode features Morty and Summer getting high on an alien spaceship's break fluid. Summer even comments on the pipe they are smoking it like a bong. They also smoke a hookah like pipe, and they are shown smoking it, coughing and their eyes turn to a different color. This is one of the most graphic scenes of drug use.
A man is shown snorting a large pile of cocaine and he is shown with a heroin syringe in his chest. This is all in a different reality because it is a main character, and another main character drinks quite heavily in this reality.
One episode shows 2 characters smoking weed. Another episode shows 2 characters also smoking weed, and there are other scenes where characters smoke joints and bongs. There is also one scene showing many people smoking joints.
Mask Off by Future plays referencing taking molly and percocet. Rick and Morty's dragon drink beer and smoke joints while listening to the song. One briefly licks something that's coated in molly and percocet, and this is meant to be funny. The song talks about drug use and this episode has some drug use.
Characters smoke joints and bongs and cut up and snort cocaine. Many people smoke joints and bongs and 2 people are shown cutting up cocaine one snorts it and one has a joint in there hand. Some paraphernalia like rolled up joints, bongs, lines of cocaine, marijuana bowls, brownie edibles, cigarette butts, rolling paper and tonnnns of bottles of alcohol
At a party, tons of underage drinking shown, including a large keg with beer being drank. Also, an ashtray with tons of cigarettes butts are shown too.
A party in the 2nd season shows a woman snorting a green powdered substance and people drink and smoke weed (although this is only implied) rick is also shown holding a hookah pipe and he is sitting next to an ashtray with alien cigarette butts (then are black instead of the normal orangish)
A drug den is shown with pills, powders, rolling paper, etc.
Morty's mother is a functional alcoholic. However, she does resent her children for thinking they're holding her back.
It is implied that Morty has FAS. Which means that his mother, Beth, drank alcohol while she was pregnant with him causing brain damage.
There are also verbal references to use of heroin.
Rick abuses his control over his alcohol problem. He uses alcohol in every episode and is shown drinking frequently.
Rick crushes an unknown foreign drug from another dimension and snorts it, resulting in his hyperactivity. The actual scene is implied and does not show any graphic drug use. Also, Rick is shown with an alien smoking weed.