Nightwalker: Midnight Detective (1998)

Mankind is threatened by a race of creatures called the Nightbreed, people who have, either willingly or through deception, succumbed to supernatural beings. And hunting them down is a man named Shido. A detective. A warrior. A vampire. And with the help of an urban spirit, his naive secretary, and a police agent assigned to special cases, Shido stands as a vanguard against the Nightbreed. But he has his own difficulties as well. Including his sire, the mysterious Cain, and his prophecies of the Golden Dawn...