Lot's of discussion of love and sexuality.

Occasional scenes where characters get kind of "feelsy" with each other. Kissing, groping, ect.

Chise often sustains battle damage and her clothes become ripped, usually her bra and areas of bare skin are visible. This isn't sexualized.

One ongoing subplot involves the fact that Shuji had sexual relations with a teacher when he was in middle school. The teacher in question is still now trying to engage with him even in high school.

This is an anime where war plays a very large part, that being said it is more of a background element that shapes the characters.

Scenes of destruction and ruin.

Lot's of talk by soldiers about how they know they are going to die and their various reactions to it.

Some soldiers die onscreen, blood is present in some cases.

everyone on earth dies eather by war, disasters or chise

Infrequent swearing in the dub.

The whole show is very heavy in tone and will upset those who are easily distressed.

chise' s hybrid from and the last battle