Drinking is shown in an non-glamourised manner, characters vomit or collapse after excessive drinking. Drinking is a major theme for the main character, implied to drink regularly.
References to drugs such as marijuana, cocaine and crystal meth. These drugs are not shown.
Mind-altering drugs are referenced to in a horrific way, causing gory death to those who didn't give in to the drugs, such as their faces melting into a bloody mess. Quite disgusting.
References to lethal injection. Quite horrific, played for black comedy.
Fictional drugs are sold on the street in a dystopian future, such as "Override" and "Fantasy". Played for laughs.