The boys discuss some pretty grotesque stuff on occasion

Really depends on the game they're playing.

Every swear word imaginable is said very regularly.

Some swear words are censored with the iconic Donkey kong roar sound effect.

Occasionally there's discussions about weed, references to drugs, etc.

Practically none. Most, if not all episodes are meant to make you slap your thighs together. Come on everypony, smile, smile, smile!