Like the film 'Waking Life', The Midnight Gospel deals with existentialist topics regarding death, religion, drug abuse and much more. Character's anxieties and regrets are mentioned frequently.
"The Midnight Gospel", albeit a science fantasy dark dramedy, has a consistent theme throughout all of its episodes; all episodes deal with heavy topics such as drugs, pregnancy and the afterlife, sorcery and other forms of ritualistic magic, emotional connection, self-awareness, meditation and self-acceptance, institutionalization of death, and the concept of birth, life, and death altogether and accepting death as it is.