Stuck with Each Other (1989)

Two luckless New Yorkers, a salesman and a secretary respectively. One morning they come to the office to find that their boss has dropped dead--leaving behind an open safe containing $964,000 he's not supposed to have. Crenna and Daly divide the illicit funds between them, and are immediately pursued by two thick-eared thugs (Michael J. Pollard, Bubba Smith). Thus for the rest of the film, Crenna and Daly are reluctantly paired as a united front against the bad guys.