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The film tells the story of Michael (Oscar Isaac), a young Armenian who dreams of studying medicine. When he travels to Constantinople to study, he meets Armenian Ana (Charlotte Le Bon) and falls in love with her, although she dates the American photographer Chris (Christian Bale), sent to Turkey to record the first genocide of the 20th century when the Turks exterminated the Armenian minority. A love triangle settles amidst the horrors of war.