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The unnamed Subject 13 is introduced to his new home in a quarantine/ medical trial by the friendly and naive Nurse Jason. During the first few days, Subject 13 bonds with Subject 50, who is staying in the room next door. Through spurious flashbacks, we see the events leading up to Subject 13's trial and how his own failings led him to lose his job and relationship. During his time on the trial, Subject 13 is haunted by the Murder Scarecrow, a character from a series of bad horror films Subject 13 binges while suffering through the study.